Journal of Veterinary and Biomedical Sciences


Journal of Veterinary and Biomedical Sciences

(ISSN: 2659 – 0743)

Volume 1, No. 2,  2018
Pages 85-94


Evaluation of Anti-inflammatory And Analgesic Activities of Methanolic Extract of Mitragyna Inermis 

Onakpa, M.M.1“, Ezugwu, C.G.1‘, Ode, J.O’., Kolawole, V.O.2’ and Ajagbonna, O.P.1
1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, PMB 117, Abuja. Nigeria.
*2Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Abuja, PMB 117 Abuja.


Inflammation is a pervasive phenomenon elicited by the body in response to obnoxious stimuli as a protective measure. However, a sustained inflammation lead to several diseases including cancer therefore the necessity to neutralize inflammation is paramount. Mitragyna inermis is a medicinal plant traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects have not been evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of M. inermis were studied in Wistar rats by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the
analgesic activity whereas paw edema model for acute inflammation using egg albumin were used to study the anti-inflammatory activity. The administration of 250 and 300 mg/kg to rats reduced pain and inflammation indicating that M. inermis possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in rats receiving 300 mg/kg of M. inermis extract. This study indicates that methanolic extract of M. inermis possess both anti-inflammatory and analgesic activities.

Keywords: Mitragyna inermis, Analgesic, Anti-inflammatory, Rats

Download PDF